But high activity of the enzyme in the right context.

In this scholarly study, mice genetically designed to have Alzheimer's-like symptoms and plaques had been bred with mice engineered to overexpress ACE in immune cells in the blood. The offspring of the two strains had greatly reduced beta-amyloid protein levels and inflammation and their performance on learning and storage tests was similar to that of regular mice. Related StoriesMyriad RBM's DiscoveryMAP platform identifies protein biomarkers linked to CV events in diabetes patientsPresident and CEO of Protein Sciences elected as 2015 Fellow of the International Culture for VaccinesUnique, tiny proteins cage developed to provide chemotherapy chemicals directly to cancer cells The analysis spotlights ACE as a naturally occurring enzyme that can have either detrimental or beneficial effects, depending on how and where it is active.For example, kidney-specific VHL deletion in mice does not elicit clear cell-specific tumor development, suggesting that additional mechanisms are in play. Toward answering that hunch, recent large-level sequencing analyses have revealed the loss of many epigenetic enzymes in certain types of ccRCCs, suggesting that changes within the nucleus take into account kidney tumor progression also. To complement genetic studies revealing a job for epigenetic enzymes, the group evaluated metabolic enzymes in the 600-plus tumors they analyzed.